Stat3-induced S1PR1 expression is critical for persistent Stat3 activation in tumors

IL-6/Jak2 signaling is viewed critical for persistent Stat3 activation in cancer. However, IL-6-induced Stat3 activity is transient in normal physiology. Here we identify a mechanism important for persistent Stat3 activation in tumor cells and the tumor microenvironment. We show that sphingosine-1-p...

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Detalhes bibliográficos
Main Authors: Lee, Heehyoung, Deng, Jiehui, Kujawski, Maciej, Yang, Chunmei, Liu, Yong, Herrmann, Andreas, Kortylewski, Marcin, Horne, David, Somlo, George, Forman, Stephen, Jove, Richard, Yu, Hua
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3088498/
https://ncbi.nlm.nih.gov/pubmed/21102457
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.2250
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