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S1PR1 is crucial for accumulation of regulatory T cells in tumors via STAT3

S1PR1 signaling has been shown to restrain the number and function of Tregs in the periphery under physiological conditions and in colitis models, but its role in regulating tumor-associated T cells is unknown. Here, we show that S1PR1 signaling in T cells drives Treg accumulation in tumors, limits...

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Detalhes bibliográficos
Main Authors: Priceman, Saul J., Shen, Shudan, Wang, Lin, Deng, Jiehui, Yue, Chanyu, Kujawski, Maciej, Yu, Hua
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3988983/
https://ncbi.nlm.nih.gov/pubmed/24630990
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2014.02.016
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