Persistently-activated Stat3 maintains constitutive NF-κB activity in tumors

NF-κB (RelA) is constitutively active in many cancers where it up-regulates anti-apoptotic and other oncogenic genes. While proinflammatory stimulus-induced NF-κB activation involves IKK-dependent nuclear translocation, mechanisms for maintaining constitutive NF-κB activity in tumors have not been e...

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Detalhes bibliográficos
Main Authors: Lee, Heehyoung, Herrmann, Andreas, Deng, JieHui, Kujawski, Maciej, Niu, Guilian, Li, Zhiwei, Forman, Steve, Jove, Richard, Pardoll, Drew, Yu, Hua
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2777654/
https://ncbi.nlm.nih.gov/pubmed/19345327
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2009.02.015
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