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Trapping and structure determination of an intermediate in the allosteric transition of aspartate transcarbamoylase
X-ray crystallography and small-angle X-ray scattering (SAXS) in solution have been used to show that a mutant aspartate transcarbamoylase exists in an intermediate quaternary structure between the canonical T and R structures. Additionally, the SAXS data indicate a pH-dependent structural alteratio...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
National Academy of Sciences
2012
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3356622/ https://ncbi.nlm.nih.gov/pubmed/22547808 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1119683109 |
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