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Time Evolution of the Quaternary Structure of Escherichia coli Aspartate Transcarbamoylase upon Reaction with the Natural Substrates and a Slow Tight Binding Inhibitor

Here we present a study of the conformational changes of the quaternary structure of E. coli aspartate transcarbamoylase (ATCase), as monitored by time-resolved small-angle X-ray scattering (TR-SAXS), upon combining with substrates, substrate analogs, and nucleotide effectors at temperatures between...

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Detalhes bibliográficos
Main Authors: West, Jay M., Xia, Jiarong, Tsuruta, Hiro, Guo, Wenyue, O’Day, Elizabeth M., Kantrowitz, Evan R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2656920/
https://ncbi.nlm.nih.gov/pubmed/18823998
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2008.09.022
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