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A Second Allosteric Site in E. coli Aspartate Transcarbamoylase
E. coli aspartate transcarbamoylase is feedback inhibited by CTP and by UTP in the presence of CTP. Here, we show by X-ray crystallography that UTP binds to a unique site on each regulatory chain of the enzyme that is near to but not overlapping with the known CTP site. These results bring into ques...
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| Main Authors: | , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2012
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3428212/ https://ncbi.nlm.nih.gov/pubmed/22667327 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi3006219 |
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