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A Second Allosteric Site in E. coli Aspartate Transcarbamoylase
E. coli aspartate transcarbamoylase is feedback inhibited by CTP and by UTP in the presence of CTP. Here, we show by X-ray crystallography that UTP binds to a unique site on each regulatory chain of the enzyme that is near to but not overlapping with the known CTP site. These results bring into ques...
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| Autors principals: | , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2012
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3428212/ https://ncbi.nlm.nih.gov/pubmed/22667327 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi3006219 |
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