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TGF-β1 INDUCES ENDOTHELIAL CELL APOPTOSIS BY SHIFTING VEGF ACTIVATION OF p38(MAPK) FROM THE PRO-SURVIVAL p38β TO PRO-APOPTOTIC p38α
Transforming growth factor-beta1 (TGF-β1) and vascular endothelial growth factor (VEGF), both angiogenesis inducers, have opposing effects on vascular endothelial cells. TGF-β1 induces apoptosis; VEGF induces survival. We have previously shown that TGF-β1 induces endothelial cell expression of VEGF,...
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| Main Authors: | , , , , , , , |
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| פורמט: | Artigo |
| שפה: | Inglês |
| יצא לאור: |
2012
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| נושאים: | |
| גישה מקוונת: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3356490/ https://ncbi.nlm.nih.gov/pubmed/22522454 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1541-7786.MCR-11-0507 |
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