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Subunit-Selective Allosteric Inhibition of Glycine Binding to NMDA Receptors

NMDA receptors are ligand-gated ion channels that mediate excitatory neurotransmission in the brain and are involved in numerous neuropathological conditions. NMDA receptors are activated upon simultaneous binding of coagonists glycine and glutamate to the GluN1 and GluN2 subunits, respectively. Sub...

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Detalles Bibliográficos
Autores principales: Hansen, Kasper B., Ogden, Kevin K., Traynelis, Stephen F.
Formato: Artigo
Lenguaje:Inglês
Publicado: Society for Neuroscience 2012
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3355950/
https://ncbi.nlm.nih.gov/pubmed/22553026
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.5757-11.2012
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