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Allosteric interaction between zinc and glutamate binding domains on NR2A causes desensitization of NMDA receptors

Fast desensitization is an important regulatory mechanism of neuronal NMDA receptor function. Previous work suggests that fast desensitization of NR1/NR2A receptors is caused by ambient zinc, and that a positive allosteric interaction occurs between the extracellular zinc-binding amino terminal doma...

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Detalhes bibliográficos
Main Authors: Erreger, Kevin, Traynelis, Stephen F
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2005
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1464251/
https://ncbi.nlm.nih.gov/pubmed/16166158
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2005.095497
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