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Allosteric interaction between zinc and glutamate binding domains on NR2A causes desensitization of NMDA receptors
Fast desensitization is an important regulatory mechanism of neuronal NMDA receptor function. Previous work suggests that fast desensitization of NR1/NR2A receptors is caused by ambient zinc, and that a positive allosteric interaction occurs between the extracellular zinc-binding amino terminal doma...
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| 主要な著者: | , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Blackwell Science Inc
2005
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1464251/ https://ncbi.nlm.nih.gov/pubmed/16166158 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2005.095497 |
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