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Allosteric interaction between zinc and glutamate binding domains on NR2A causes desensitization of NMDA receptors
Fast desensitization is an important regulatory mechanism of neuronal NMDA receptor function. Previous work suggests that fast desensitization of NR1/NR2A receptors is caused by ambient zinc, and that a positive allosteric interaction occurs between the extracellular zinc-binding amino terminal doma...
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| Autors principals: | , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Blackwell Science Inc
2005
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1464251/ https://ncbi.nlm.nih.gov/pubmed/16166158 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2005.095497 |
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