CYP2A6 genetic variation and dexmedetomidine disposition

PURPOSE: There is a large interindividual variability in dexmedetomidine dose requirements for sedation of patients in intensive care units (ICU). Cytochrome P450 2A6 (CYP2A6) mediates an important route of dexmedetomidine metabolism, and genetic variation in CYP2A6 affects the clearance of other su...

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Main Authors: Kohli, Utkarsh, Pandharipande, Pratik, Muszkat, Mordechai, Sofowora, Gbenga G., Friedman, Eitan A., Scheinin, Mika, Wood, Alastair J. J., Ely, E. Wesley, Tyndale, Rachel F., Choi, Leena, Stein, C. Michael, Kurnik, Daniel
Format: Artigo
Jezik:Inglês
Izdano: 2012
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3352974/
https://ncbi.nlm.nih.gov/pubmed/22271297
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00228-011-1208-z
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