CYP2A6 genetic variation and dexmedetomidine disposition

PURPOSE: There is a large interindividual variability in dexmedetomidine dose requirements for sedation of patients in intensive care units (ICU). Cytochrome P450 2A6 (CYP2A6) mediates an important route of dexmedetomidine metabolism, and genetic variation in CYP2A6 affects the clearance of other su...

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Detalhes bibliográficos
Main Authors: Kohli, Utkarsh, Pandharipande, Pratik, Muszkat, Mordechai, Sofowora, Gbenga G., Friedman, Eitan A., Scheinin, Mika, Wood, Alastair J. J., Ely, E. Wesley, Tyndale, Rachel F., Choi, Leena, Stein, C. Michael, Kurnik, Daniel
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3352974/
https://ncbi.nlm.nih.gov/pubmed/22271297
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00228-011-1208-z
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