Variation in the α(2A)-adrenoceptor gene and the effect of dexmedetomidine on plasma insulin and glucose

OBJECTIVES: Sympathetic activation inhibits insulin secretion through activation of pancreatic α(2A)-adrenoreceptors (α(2A)ARs). A common genetic α(2A)AR variant (rs553668) is associated with impaired insulin secretion. α(2)AR-agonists would be expected to decrease insulin secretion, but their effec...

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Bibliografski detalji
Glavni autori: Ghimire, Laxmi V., Muszkat, Mordechai, Sofowora, Gbenga G., Scheinin, Mika, Wood, Alastair J.J., Stein, C. Michael, Kurnik, Daniel
Format: Artigo
Jezik:Inglês
Izdano: 2013
Teme:
Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3787837/
https://ncbi.nlm.nih.gov/pubmed/23873118
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/FPC.0b013e3283642f93
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