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GRK5 Gln41Leu polymorphism is not associated with sensitivity to β(1)-adrenergic blockade in humans
AIMS: A common, functionally significant polymorphism in GRK5 (Gln41Leu) encodes a gain-of-function enzyme that enhances desensitization of the β(1)-adrenergic receptor. GRK5 Leu41 has been postulated to confer endogenous ‘genetic β-blockade’ and contribute to an attenuated response to β-blockers in...
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| Main Authors: | , , , , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2009
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2820245/ https://ncbi.nlm.nih.gov/pubmed/19842931 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2217/pgs.09.92 |
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