GRK5 Gln41Leu polymorphism is not associated with sensitivity to β(1)-adrenergic blockade in humans

AIMS: A common, functionally significant polymorphism in GRK5 (Gln41Leu) encodes a gain-of-function enzyme that enhances desensitization of the β(1)-adrenergic receptor. GRK5 Leu41 has been postulated to confer endogenous ‘genetic β-blockade’ and contribute to an attenuated response to β-blockers in...

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Bibliografiset tiedot
Päätekijät: Kurnik, Daniel, Cunningham, Andrew J, Sofowora, Gbenga G, Kohli, Utkarsh, Li, Chun, Friedman, Eitan A, Muszkat, Mordechai, Menon, Usha B, Wood, Alastair JJ, Stein, C Michael
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2009
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC2820245/
https://ncbi.nlm.nih.gov/pubmed/19842931
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2217/pgs.09.92
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