Increased Sp1 binding mediates erythroid-specific overexpression of a mutated (HPFH) gamma-globulin promoter.

The -198 T----C mutation in the promoter of the A gamma-globin gene increases 20-30 fold the expression of this gene in adult erythroid cells of patients (Hereditary Persistence of Fetal Hemoglobin, HPFH). We show here that this mutation creates a strong binding site, resembling a CACCC box, for two...

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Pubblicato in:	Nucleic Acids Res
Autori principali:	Ronchi, A, Nicolis, S, Santoro, C, Ottolenghi, S
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Oxford University Press 1989
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC335297/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2481268/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/17.24.10231
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