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Increased erythroid-specific expression of a mutated HPFH gamma-globin promoter requires the erythroid factor NFE-1.

The -175 T greater than C mutation in the promoter of the A gamma- or G gamma-globin gene causes a 50-100 fold increase of the expression of the respective gene in adult erythroid cells (Hereditary Persistence of Fetal Hemoglobin). We show here that this mutation increases 3-9 fold the expression of...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Nicolis, S, Ronchi, A, Malgaretti, N, Mantovani, R, Giglioni, B, Ottolenghi, S
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 1989
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC318174/
https://ncbi.nlm.nih.gov/pubmed/2474800
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