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Increased erythroid-specific expression of a mutated HPFH gamma-globin promoter requires the erythroid factor NFE-1.

The -175 T greater than C mutation in the promoter of the A gamma- or G gamma-globin gene causes a 50-100 fold increase of the expression of the respective gene in adult erythroid cells (Hereditary Persistence of Fetal Hemoglobin). We show here that this mutation increases 3-9 fold the expression of...

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Bibliografiske detaljer
Main Authors: Nicolis, S, Ronchi, A, Malgaretti, N, Mantovani, R, Giglioni, B, Ottolenghi, S
Format: Artigo
Sprog:Inglês
Udgivet: 1989
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC318174/
https://ncbi.nlm.nih.gov/pubmed/2474800
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