Increased erythroid-specific expression of a mutated HPFH gamma-globin promoter requires the erythroid factor NFE-1.

The -175 T greater than C mutation in the promoter of the A gamma- or G gamma-globin gene causes a 50-100 fold increase of the expression of the respective gene in adult erythroid cells (Hereditary Persistence of Fetal Hemoglobin). We show here that this mutation increases 3-9 fold the expression of...

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Publié dans:	Nucleic Acids Res
Auteurs principaux:	Nicolis, S, Ronchi, A, Malgaretti, N, Mantovani, R, Giglioni, B, Ottolenghi, S
Format:	Artigo
Langue:	Inglês
Publié:	Oxford University Press 1989
Accès en ligne:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC318174/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2474800/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/17.14.5509
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