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Increased Sp1 binding mediates erythroid-specific overexpression of a mutated (HPFH) gamma-globulin promoter.

The -198 T----C mutation in the promoter of the A gamma-globin gene increases 20-30 fold the expression of this gene in adult erythroid cells of patients (Hereditary Persistence of Fetal Hemoglobin, HPFH). We show here that this mutation creates a strong binding site, resembling a CACCC box, for two...

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Autors principals: Ronchi, A, Nicolis, S, Santoro, C, Ottolenghi, S
Format: Artigo
Idioma:Inglês
Publicat: 1989
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC335297/
https://ncbi.nlm.nih.gov/pubmed/2481268
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