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The -117 mutation in Greek HPFH affects the binding of three nuclear factors to the CCAAT region of the gamma-globin gene.

The Greek form of hereditary persistence of fetal hemoglobin (HPFH) is associated with a point mutation immediately upstream of the distal of the two CCAAT elements of the A gamma-globin gene. Three proteins present in nuclear extracts of erythroleukemia cells bind to this CCAAT region and contact t...

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Hlavní autoři: Superti-Furga, G, Barberis, A, Schaffner, G, Busslinger, M
Médium: Artigo
Jazyk:Inglês
Vydáno: 1988
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC454699/
https://ncbi.nlm.nih.gov/pubmed/3181130
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