The -117 mutation in Greek HPFH affects the binding of three nuclear factors to the CCAAT region of the gamma-globin gene.

Lignende værker

• The deletion of the distal CCAAT box region of the A gamma-globin gene in black HPFH abolishes the binding of the erythroid specific protein NFE3 and of the CCAAT displacement protein.
  af: Mantovani, R, et al.
  Udgivet: (1989)
• The effects of HPFH mutations in the human gamma-globin promoter on binding of ubiquitous and erythroid specific nuclear factors.
  af: Mantovani, R, et al.
  Udgivet: (1988)
• Restriction endonuclease mapping of gamma-delta-beta-globin region in G gamma (beta)+ HPFH and a Chinese A gamma HPFH variant.
  af: Farquhar, M, et al.
  Udgivet: (1983)
• Distal CCAAT box deletion in the A gamma globin gene of two black adolescents with elevated fetal A gamma globin.
  af: Gilman, J G, et al.
  Udgivet: (1988)
• A novel C-T transition within the distal CCAAT motif of the G gamma-globin gene in the Japanese HPFH: implication of factor binding in elevated fetal globin expression.
  af: Fucharoen, S, et al.
  Udgivet: (1990)