Mechanism of Nucleic Acid Unwinding by SARS-CoV Helicase

The non-structural protein 13 (nsp13) of Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) is a helicase that separates double-stranded RNA (dsRNA) or DNA (dsDNA) with a 5′→3′ polarity, using the energy of nucleotide hydrolysis. We determined the minimal mechanism of helicase function by nsp1...

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Main Authors: Adedeji, Adeyemi O., Marchand, Bruno, te Velthuis, Aartjan J. W., Snijder, Eric J., Weiss, Susan, Eoff, Robert L., Singh, Kamalendra, Sarafianos, Stefan G.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2012
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3352918/
https://ncbi.nlm.nih.gov/pubmed/22615777
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0036521
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