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STRUCTURAL AND BIOCHEMICAL BASIS FOR THE DIFFERENCE IN THE HELICASE ACTIVITY OF TWO DIFFERENT CONSTRUCTS OF SARS-COV HELICASE

The non-structural protein 13 (nsp13) of Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) is a helicase that separates double-stranded RNA or DNA with a 5’-3’ polarity, using the energy of nucleotide hydrolysis. We have previously determined the minimal mechanism of helicase function by nsp1...

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Main Authors: Adedeji, Adeyemi O., Singh, Kamalendra, Sarafianos, Stefan G.
格式: Artigo
語言:Inglês
出版: 2012
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3612351/
https://ncbi.nlm.nih.gov/pubmed/23273200
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