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Force-dependent stimulation of RNA unwinding by SARS-CoV-2 nsp13 helicase
The superfamily-1 helicase non-structural protein 13 (nsp13) is required for SARS-CoV-2 replication, making it an important antiviral therapeutic target. The mechanism and regulation of nsp13 has not been explored at the single-molecule level. Specifically, force-dependent unwinding experiments have...
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| Publicado no: | bioRxiv |
|---|---|
| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Cold Spring Harbor Laboratory
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7402037/ https://ncbi.nlm.nih.gov/pubmed/32766580 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/2020.07.31.231274 |
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