Force-dependent stimulation of RNA unwinding by SARS-CoV-2 nsp13 helicase

The superfamily-1 helicase non-structural protein 13 (nsp13) is required for SARS-CoV-2 replication, making it an important antiviral therapeutic target. The mechanism and regulation of nsp13 has not been explored at the single-molecule level. Specifically, force-dependent unwinding experiments have...

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Vydáno v:bioRxiv
Hlavní autoři: Mickolajczyk, Keith J, Shelton, Patrick M M, Grasso, Michael, Cao, Xiaocong, Warrington, Sara R, Aher, Amol, Liu, Shixin, Kapoor, Tarun M
Médium: Artigo
Jazyk:Inglês
Vydáno: Cold Spring Harbor Laboratory 2020
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7402037/
https://ncbi.nlm.nih.gov/pubmed/32766580
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/2020.07.31.231274
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