Synthesis of Purine Modified 2′-C-Methyl Nucleosides as Potential Anti-HCV Agents

Based on the anti-hepatitis C activity of 2′-C-methyl-adenosine and 2′-C-methyl-guanosine, a series of new modified purine 2′-C-methyl nucleosides was prepared as potential anti-hepatitis C virus agents. Herein, we report the synthesis of both 6-modified and 2-modified purine 2′-C-methyl-nucleosides...

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Huvudupphovsmän: Zhang, Hong-wang, Zhou, Longhu, Coats, Steven J., McBrayer, Tamara R., Tharnish, Phillip M., Bondada, Lavanya, Detorio, Mervi, Amichai, Sarah A., Johns, Melissa D., Whitaker, Tony, Schinazi, Raymond F.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2011
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3352596/
https://ncbi.nlm.nih.gov/pubmed/21983447
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2011.09.034
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