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Oxidative Genome Damage and Its repair: Implications in Aging and Neurodegenerative Diseases
Reactive oxygen species (ROS), generated endogenously during respiration or exogenously by genotoxic agents, induce oxidized bases and single-strand breaks (SSBs) in DNA that are repaired via the base excision/SSB repair (BER/SSBR) pathway in both the nucleus and mitochondria. Tightly regulated BER/...
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| Главные авторы: | , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2012
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3351531/ https://ncbi.nlm.nih.gov/pubmed/22313689 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mad.2012.01.005 |
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