Specific Inhibition of NEIL-initiated Repair of Oxidized Base Damage in Human Genome by Copper and Iron: POTENTIAL ETIOLOGICAL LINKAGE TO NEURODEGENERATIVE DISEASES

Dyshomeostasis of transition metals iron and copper as well as accumulation of oxidative DNA damage have been implicated in multitude of human neurodegenerative diseases, including Alzheimer disease and Parkinson disease. These metals oxidize DNA bases by generating reactive oxygen species. Most oxi...

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Main Authors: Hegde, Muralidhar L., Hegde, Pavana M., Holthauzen, Luis M. F., Hazra, Tapas K., Rao, K. S. Jagannatha, Mitra, Sankar
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
DNA and Chromosomes
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2937909/
https://ncbi.nlm.nih.gov/pubmed/20622253
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.126664
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