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Age-dependent deficiency in import of mitochondrial DNA glycosylases required for repair of oxidatively damaged bases
The mitochondria are the major source of chronic oxidative stress, which has been implicated in the aging process. Along with other cellular changes, aged cells accumulate mutations in both their nuclear and mitochondrial genomes, and they contain increased amounts of oxidatively damaged mutagenic b...
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| Hoofdauteurs: | , , , , |
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| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
National Academy of Sciences
2003
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC196862/ https://ncbi.nlm.nih.gov/pubmed/12960370 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1932854100 |
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