Deficiency in Repair of the Mitochondrial Genome Sensitizes Proliferating Myoblasts to Oxidative Damage

Reactive oxygen species (ROS), generated as a by-product of mitochondrial oxidative phosphorylation, are particularly damaging to the genome of skeletal muscle because of their high oxygen consumption. Proliferating myoblasts play a key role during muscle regeneration by undergoing myogenic differen...

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Main Authors: Szczesny, Bartosz, Olah, Gabor, Walker, Dillon K., Volpi, Elena, Rasmussen, Blake B., Szabo, Csaba, Mitra, Sankar
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2013
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3774773/
https://ncbi.nlm.nih.gov/pubmed/24066171
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0075201
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