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Age-dependent deficiency in import of mitochondrial DNA glycosylases required for repair of oxidatively damaged bases

The mitochondria are the major source of chronic oxidative stress, which has been implicated in the aging process. Along with other cellular changes, aged cells accumulate mutations in both their nuclear and mitochondrial genomes, and they contain increased amounts of oxidatively damaged mutagenic b...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς: Szczesny, Bartosz, Hazra, Tapas K., Papaconstantinou, John, Mitra, Sankar, Boldogh, Istvan
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: National Academy of Sciences 2003
Θέματα:
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC196862/
https://ncbi.nlm.nih.gov/pubmed/12960370
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1932854100
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