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Oxidative Genome Damage and Its repair: Implications in Aging and Neurodegenerative Diseases

Reactive oxygen species (ROS), generated endogenously during respiration or exogenously by genotoxic agents, induce oxidized bases and single-strand breaks (SSBs) in DNA that are repaired via the base excision/SSB repair (BER/SSBR) pathway in both the nucleus and mitochondria. Tightly regulated BER/...

詳細記述

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書誌詳細
主要な著者: Hegde, Muralidhar L., Mantha, Anil K., Hazra, Tapas K., Bhakat, Kishor K., Mitra, Sankar, Szczesny, Bartosz
フォーマット: Artigo
言語:Inglês
出版事項: 2012
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3351531/
https://ncbi.nlm.nih.gov/pubmed/22313689
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mad.2012.01.005
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