Oxidative Genome Damage and Its repair: Implications in Aging and Neurodegenerative Diseases

Reactive oxygen species (ROS), generated endogenously during respiration or exogenously by genotoxic agents, induce oxidized bases and single-strand breaks (SSBs) in DNA that are repaired via the base excision/SSB repair (BER/SSBR) pathway in both the nucleus and mitochondria. Tightly regulated BER/...

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Hauptverfasser: Hegde, Muralidhar L., Mantha, Anil K., Hazra, Tapas K., Bhakat, Kishor K., Mitra, Sankar, Szczesny, Bartosz
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2012
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3351531/
https://ncbi.nlm.nih.gov/pubmed/22313689
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mad.2012.01.005
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