NMR Studies of Hexaacylated Endotoxin Bound to Wild-type and F126A Mutant MD-2 and MD-2·TLR4 Ectodomain Complexes

Host response to invasion by many Gram-negative bacteria depends upon activation of Toll-like receptor 4 (TLR4) by endotoxin presented as a monomer bound to myeloid differentiation factor 2 (MD-2). Metabolic labeling of hexaacylated endotoxin (LOS) from Neisseria meningitidis with [(13)C]acetate all...

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Main Authors: Yu, Liping, Phillips, Rachel L., Zhang, DeSheng, Teghanemt, Athmane, Weiss, Jerrold P., Gioannini, Theresa L.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Immunology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3351295/
https://ncbi.nlm.nih.gov/pubmed/22433852
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.343467
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