The molecular basis of ATM-dependent dimerization of the Mdc1 DNA damage checkpoint mediator

Mdc1 is a large modular phosphoprotein scaffold that maintains signaling and repair complexes at double-stranded DNA break sites. Mdc1 is anchored to damaged chromatin through interaction of its C-terminal BRCT-repeat domain with the tail of γH2AX following DNA damage, but the role of the N-terminal...

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Detalhes bibliográficos
Main Authors: Jungmichel, Stephanie, Clapperton, Julie A., Lloyd, Janette, Hari, Flurina J., Spycher, Christoph, Pavic, Lucijana, Li, Jiejin, Haire, Lesley F., Bonalli, Mario, Larsen, Dorthe H., Lukas, Claudia, Lukas, Jiri, MacMillan, Derek, Nielsen, Michael L., Stucki, Manuel, Smerdon, Stephen J.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2012
Assuntos:
Genome Integrity, Repair and Replication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3351161/
https://ncbi.nlm.nih.gov/pubmed/22234878
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkr1300
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