A super-modular FHA/BRCT-repeat architecture mediates Nbs1 adaptor function in response to DNA-damage

The Mre11/Rad50/Nbs1 (MRN) protein complex plays central enzymatic and signaling roles in the DNA-damage response. Nuclease (Mre11) and scaffolding (Rad50) components of MRN have been extensively characterized but the molecular basis of Nbs1 function has remained elusive. Here, we present a 2.3Å cry...

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Detalhes bibliográficos
Main Authors: Lloyd, Janette, Chapman, J. Ross, Clapperton, Julie A., Haire, Lesley F., Hartsuiker, Edgar, Li, Jiejin, Carr, Antony M., Jackson, Stephen P., Smerdon, Stephen J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2900601/
https://ncbi.nlm.nih.gov/pubmed/19804756
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2009.07.043
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