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A divalent FHA/BRCT-binding mechanism couples the MRE11–RAD50–NBS1 complex to damaged chromatin
The MRE11–RAD50–NBS1 (MRN) complex accumulates at sites of DNA double-strand breaks in large chromatin domains flanking the lesion site. The mechanism of MRN accumulation involves direct binding of the Nijmegen breakage syndrome 1 (NBS1) subunit to phosphorylated mediator of the DNA damage checkpoin...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2868538/ https://ncbi.nlm.nih.gov/pubmed/20224574 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/embor.2010.30 |
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