A divalent FHA/BRCT-binding mechanism couples the MRE11–RAD50–NBS1 complex to damaged chromatin

The MRE11–RAD50–NBS1 (MRN) complex accumulates at sites of DNA double-strand breaks in large chromatin domains flanking the lesion site. The mechanism of MRN accumulation involves direct binding of the Nijmegen breakage syndrome 1 (NBS1) subunit to phosphorylated mediator of the DNA damage checkpoin...

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Autori principali: Hari, Flurina J, Spycher, Christoph, Jungmichel, Stephanie, Pavic, Lucijana, Stucki, Manuel
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2010
Soggetti:
Scientific Reports
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2868538/
https://ncbi.nlm.nih.gov/pubmed/20224574
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/embor.2010.30
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