The NBS1-Treacle complex controls ribosomal RNA transcription in response to DNA damage

Chromosome breakage elicits transient silencing of ribosomal RNA synthesis, but the mechanisms involved remained elusive. Here we discover an in-trans signaling mechanism that triggers pan-nuclear silencing of rRNA transcription in response to DNA damage. This is associated with transient recruitmen...

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Detalhes bibliográficos
Publicado no:Nat Cell Biol
Main Authors: Larsen, Dorthe H, Hari, Flurina, Clapperton, Julie A, Gwerder, Myriam, Gutsche, Katrin, Altmeyer, Matthias, Jungmichel, Stephanie, Toledo, Luis I, Fink, Daniel, Rask, Maj-Britt, Grøfte, Merete, Lukas, Claudia, Nielsen, Michael L, Smerdon, Stephen J, Lukas, Jiri, Stucki, Manuel
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4962910/
https://ncbi.nlm.nih.gov/pubmed/25064736
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncb3007
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