The NBS1-Treacle complex controls ribosomal RNA transcription in response to DNA damage

Chromosome breakage elicits transient silencing of ribosomal RNA synthesis, but the mechanisms involved remained elusive. Here we discover an in-trans signaling mechanism that triggers pan-nuclear silencing of rRNA transcription in response to DNA damage. This is associated with transient recruitmen...

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發表在:Nat Cell Biol
Main Authors: Larsen, Dorthe H, Hari, Flurina, Clapperton, Julie A, Gwerder, Myriam, Gutsche, Katrin, Altmeyer, Matthias, Jungmichel, Stephanie, Toledo, Luis I, Fink, Daniel, Rask, Maj-Britt, Grøfte, Merete, Lukas, Claudia, Nielsen, Michael L, Smerdon, Stephen J, Lukas, Jiri, Stucki, Manuel
格式: Artigo
語言:Inglês
出版: 2014
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4962910/
https://ncbi.nlm.nih.gov/pubmed/25064736
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncb3007
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