The NBS1-Treacle complex controls ribosomal RNA transcription in response to DNA damage

Chromosome breakage elicits transient silencing of ribosomal RNA synthesis, but the mechanisms involved remained elusive. Here we discover an in-trans signaling mechanism that triggers pan-nuclear silencing of rRNA transcription in response to DNA damage. This is associated with transient recruitmen...

Cijeli opis

Spremljeno u:
Bibliografski detalji
Izdano u:Nat Cell Biol
Glavni autori: Larsen, Dorthe H, Hari, Flurina, Clapperton, Julie A, Gwerder, Myriam, Gutsche, Katrin, Altmeyer, Matthias, Jungmichel, Stephanie, Toledo, Luis I, Fink, Daniel, Rask, Maj-Britt, Grøfte, Merete, Lukas, Claudia, Nielsen, Michael L, Smerdon, Stephen J, Lukas, Jiri, Stucki, Manuel
Format: Artigo
Jezik:Inglês
Izdano: 2014
Teme:
Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4962910/
https://ncbi.nlm.nih.gov/pubmed/25064736
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncb3007
Oznake: Dodaj oznaku
Bez oznaka, Budi prvi tko označuje ovaj zapis!

Similar Items