Loss of the Urothelial Differentiation Marker FOXA1 Is Associated with High Grade, Late Stage Bladder Cancer and Increased Tumor Proliferation

Approximately 50% of patients with muscle-invasive bladder cancer (MIBC) develop metastatic disease, which is almost invariably lethal. However, our understanding of pathways that drive aggressive behavior of MIBC is incomplete. Members of the FOXA subfamily of transcription factors are implicated i...

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Autores principales: DeGraff, David J., Clark, Peter E., Cates, Justin M., Yamashita, Hironobu, Robinson, Victoria L., Yu, Xiuping, Smolkin, Mark E., Chang, Sam S., Cookson, Michael S., Herrick, Mary K., Shariat, Shahrokh F., Steinberg, Gary D., Frierson, Henry F., Wu, Xue-Ru, Theodorescu, Dan, Matusik, Robert J.
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3349679/
https://ncbi.nlm.nih.gov/pubmed/22590586
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0036669
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