Loss of the Urothelial Differentiation Marker FOXA1 Is Associated with High Grade, Late Stage Bladder Cancer and Increased Tumor Proliferation

Approximately 50% of patients with muscle-invasive bladder cancer (MIBC) develop metastatic disease, which is almost invariably lethal. However, our understanding of pathways that drive aggressive behavior of MIBC is incomplete. Members of the FOXA subfamily of transcription factors are implicated i...

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Main Authors: DeGraff, David J., Clark, Peter E., Cates, Justin M., Yamashita, Hironobu, Robinson, Victoria L., Yu, Xiuping, Smolkin, Mark E., Chang, Sam S., Cookson, Michael S., Herrick, Mary K., Shariat, Shahrokh F., Steinberg, Gary D., Frierson, Henry F., Wu, Xue-Ru, Theodorescu, Dan, Matusik, Robert J.
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2012
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3349679/
https://ncbi.nlm.nih.gov/pubmed/22590586
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0036669
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