Loss of the Urothelial Differentiation Marker FOXA1 Is Associated with High Grade, Late Stage Bladder Cancer and Increased Tumor Proliferation

Approximately 50% of patients with muscle-invasive bladder cancer (MIBC) develop metastatic disease, which is almost invariably lethal. However, our understanding of pathways that drive aggressive behavior of MIBC is incomplete. Members of the FOXA subfamily of transcription factors are implicated i...

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Detalhes bibliográficos
Main Authors: DeGraff, David J., Clark, Peter E., Cates, Justin M., Yamashita, Hironobu, Robinson, Victoria L., Yu, Xiuping, Smolkin, Mark E., Chang, Sam S., Cookson, Michael S., Herrick, Mary K., Shariat, Shahrokh F., Steinberg, Gary D., Frierson, Henry F., Wu, Xue-Ru, Theodorescu, Dan, Matusik, Robert J.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3349679/
https://ncbi.nlm.nih.gov/pubmed/22590586
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0036669
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