Loss of FOXA1 Drives Sexually Dimorphic Changes in Urothelial Differentiation and Is an Independent Predictor of Poor Prognosis in Bladder Cancer

We previously found loss of forkhead box A1 (FOXA1) expression to be associated with aggressive urothelial carcinoma of the bladder, as well as increased tumor proliferation and invasion. These initial findings were substantiated by The Cancer Genome Atlas, which identified FOXA1 mutations in a subs...

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Опубликовано в: :Am J Pathol
Главные авторы: Reddy, Opal L., Cates, Justin M., Gellert, Lan L., Crist, Henry S., Yang, Zhaohai, Yamashita, Hironobu, Taylor, John A., Smith, Joseph A., Chang, Sam S., Cookson, Michael S., You, Chaochen, Barocas, Daniel A., Grabowska, Magdalena M., Ye, Fei, Wu, Xue-Ru, Yi, Yajun, Matusik, Robert J., Kaestner, Klaus H., Clark, Peter E., DeGraff, David J.
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Investigative Pathology 2015
Предметы:
Regular Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4419202/
https://ncbi.nlm.nih.gov/pubmed/25907831
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2015.01.014
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