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l-Arginine supplementation abolishes the blood pressure and endothelin response to chronic increases in plasma sFlt-1 in pregnant rats

While soluble fms-like tyrosine kinase-1 (sFlt-1) and endothelin-1 (ET-1) have been implicated in the pathogenesis of preeclampsia (PE), the mechanisms whereby increased sFlt-1 leads to enhanced ET-1 production and hypertension remain unclear. It is well documented that nitric oxide (NO) production...

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Autori principali: Murphy, Sydney R., LaMarca, Babbette, Cockrell, Kathy, Arany, Marietta, Granger, Joey P.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Physiological Society 2012
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3349388/
https://ncbi.nlm.nih.gov/pubmed/22071155
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpregu.00319.2011
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