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Role of Endothelin in Mediating Soluble fms-like Tyrosine Kinase-1 (sFlt-1)-induced Hypertension in Pregnant Rats

While soluble fms-like tyrosine kinase-1 (sFlt-1), an antagonist of vascular endothelial growth factor and placental growth factor has been implicated in the pathogenesis of hypertension during preeclampsia (PE), the mechanisms whereby enhanced sFlt-1 production leads to hypertension remain unclear....

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Detalhes bibliográficos
Main Authors: Murphy, Sydney R., LaMarca, B. Babbette D., Cockrell, Kathy, Granger, Joey P.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2833966/
https://ncbi.nlm.nih.gov/pubmed/20026766
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/HYPERTENSIONAHA.109.141473
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