Prevention and reversal by cocaine esterase of cocaine-induced cardiovascular effects in rats

The present study is the first to utilize bacterial cocaine esterase (CocE) to increase elimination of a lethal dose of cocaine and evaluate its cardioprotective effects. Rats received one of 5 treatments: CocE 1 min after saline; CocE 1 min after a lethal i.p. dose of cocaine; saline 1 min after a...

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Bibliographic Details
Main Authors: Wood, Susan K., Narasimhan, Diwahar, Cooper, Ziva, Sunahara, Roger K., Woods, James H.
Format: Artigo
Language:Inglês
Published: 2009
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3349347/
https://ncbi.nlm.nih.gov/pubmed/19800183
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.drugalcdep.2009.09.001
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