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U1-snRNP activates the NLRP3 inflammasome in human monocytes
The NLRP3 (NOD-like receptor family, pyrin domain containing 3) inflammasome is a caspase-1-containing cytosolic protein complex that is essential for processing and secretion of IL-1β. The U1-small nuclear ribonucleoprotein (U1-snRNP) which includes U1-small nuclear RNA (U1-snRNA) is a highly conse...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3347773/ https://ncbi.nlm.nih.gov/pubmed/22490866 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1103355 |
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