Removal of Vaccinia Virus Genes That Block Interferon Type I and II Pathways Improves Adaptive and Memory Responses of the HIV/AIDS Vaccine Candidate NYVAC-C in Mice

Poxviruses encode multiple inhibitors of the interferon (IFN) system, acting at different levels and blocking the induction of host defense mechanisms. Two viral gene products, B19 and B8, have been shown to act as decoy receptors of type I and type II IFNs, blocking the binding of IFN to its recept...

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מידע ביבליוגרפי
Main Authors: Gómez, Carmen Elena, Perdiguero, Beatriz, Nájera, Jose Luis, Sorzano, Carlos Oscar S., Jiménez, Victoria, González-Sanz, Rubén, Esteban, Mariano
פורמט: Artigo
שפה:Inglês
יצא לאור: American Society for Microbiology 2012
נושאים:
Vaccines and Antiviral Agents
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3347383/
https://ncbi.nlm.nih.gov/pubmed/22419805
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.06684-11
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