Removal of Vaccinia Virus Genes That Block Interferon Type I and II Pathways Improves Adaptive and Memory Responses of the HIV/AIDS Vaccine Candidate NYVAC-C in Mice

Poxviruses encode multiple inhibitors of the interferon (IFN) system, acting at different levels and blocking the induction of host defense mechanisms. Two viral gene products, B19 and B8, have been shown to act as decoy receptors of type I and type II IFNs, blocking the binding of IFN to its recept...

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Bibliographische Detailangaben
Hauptverfasser: Gómez, Carmen Elena, Perdiguero, Beatriz, Nájera, Jose Luis, Sorzano, Carlos Oscar S., Jiménez, Victoria, González-Sanz, Rubén, Esteban, Mariano
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2012
Schlagworte:
Vaccines and Antiviral Agents
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3347383/
https://ncbi.nlm.nih.gov/pubmed/22419805
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.06684-11
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