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3,5-Bis(benzylidene)-1-[3-(2-hydroxyethylthio)propanoyl] piperidin-4-ones: A Novel Cluster of Potent Tumor-Selective Cytotoxins

Novel 3,5-bis(benzylidene)-1-[3-(2-hydroxyethylthio)propanoyl]piperidin-4-ones (3a–e) display potent cytotoxicity and a preferential lethality toward various neoplasms compared to some normal cells. The corresponding sulfonic acid analogues 5a–e and an isostere 4 demonstrated substantially lower act...

詳細記述

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書誌詳細
主要な著者: Das, Umashankar, Pati, Hari N., Sakagami, Hiroshi, Hashimoto, Ken, Kawase, Masami, Balzarini, Jan, De Clercq, Erik, Dimmock, Jonathan R.
フォーマット: Artigo
言語:Inglês
出版事項: 2011
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3346748/
https://ncbi.nlm.nih.gov/pubmed/21449610
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm101595p
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