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3,5-Bis(benzylidene)-1-[3-(2-hydroxyethylthio)propanoyl] piperidin-4-ones: A Novel Cluster of Potent Tumor-Selective Cytotoxins
Novel 3,5-bis(benzylidene)-1-[3-(2-hydroxyethylthio)propanoyl]piperidin-4-ones (3a–e) display potent cytotoxicity and a preferential lethality toward various neoplasms compared to some normal cells. The corresponding sulfonic acid analogues 5a–e and an isostere 4 demonstrated substantially lower act...
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| 主要な著者: | , , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2011
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| 主題: | |
| オンライン・アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3346748/ https://ncbi.nlm.nih.gov/pubmed/21449610 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm101595p |
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