Cytotoxic 3,5-bis(benzylidene)piperidin-4-ones and N-acyl analogs displaying selective toxicity for malignant cells

A series of 3,5-bis(benzylidene)piperidin-4-ones 1, 1-acryloyl-3,5-bis(benzylidene)piperidin-4-ones 2 and adducts of 2 with sodium 2-mercaptoethanesulfonate (mesna), namely series 3, were prepared as candidate cytotoxic agents. These compounds were examined against neoplastic HSC-2, HSC-4 and HL-60...

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Hlavní autoři: Pati, Hari N., Das, Umashankar, Quail, J. Wilson, Kawase, Masami, Sakagami, Hiroshi, Dimmock, Jonathan R.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2007
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3276587/
https://ncbi.nlm.nih.gov/pubmed/17499885
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2007.03.010
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