3,5-Bis(benzylidene)-1-[4-2-(morpholin-4-yl)ethoxyphenylcarbonyl]-4-piperidone hydrochloride: A lead tumor-specific cytotoxin which induces apoptosis and autophagy

A number of N-4-(2-aminoethoxy)phenylcarbonyl derivatives of various 3,5-bis(benzylidene)-4-piperidones 2–5 demonstrated noteworthy cytotoxic potencies towards human HL-60 leukemic cells as well as human HSC-2 and HSC-4 squamous cell carcinomas. In general, toxicity towards HGF, HPC, and HPLF normal...

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Detalhes bibliográficos
Main Authors: Das, Umashankar, Sakagami, Hiroshi, Chu, Qing, Wang, Qintao, Kawase, Masami, Selvakumar, Ponniah, Sharma, Rajendra K., Dimmock, Jonathan R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3276597/
https://ncbi.nlm.nih.gov/pubmed/20064715
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2009.12.076
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